Joshua Sweetwater, an American Indian student at Harvard University, is drawn into a fraternity called The Darwinian Club, a front for an organization committed to the “survival of the fittest.” Armed with biblical insight from letters written by an old family friend and the timely aid of a university janitor who is more than he appears, Joshua infiltrates the Club and exposes their devilish plots of murder and genocide.

Constance Washington, granddaughter of Josiah from Book 1, is a gifted college graduate. A black writer ahead of her time, she is hired to be a spokeswoman for a new women’s rights organization following in the footsteps of Margaret Sanger. After Constance attempts to keep a friend from having an abortion, she finds her pregnant friend the target of unexplained accidents. Stories told by her godmother strengthen her to take a stand and expose the organization’s anti-life philosophy.

Paul Vestry, grandson of Adam in Book 2, is a budding Hollywood star who must choose between his faith, money and worldly success. An ill-advised relationship with a female co-star and a shady business deal entangles him with ruthless gangsters, threatening his career and his life. However, while filming a new movie, a godly scriptwriter uses the fictional life of Paul’s movie character to open his heart to the folly of his ways and to true faith in God.

Jason Vestry, the son of Paul Vestry, is a high school senior growing up in suburban Kansas City. Like many, he is captivated by the powerful new media of television. Jason and his friends turn from play to harassment to violence against local Indians on a nearby reservation. As Jason learns about the evil potential of media manipulation from a reticent neighbor who was a former Nazi soldier, he risks his life to take a stand for the truth.

Elijah Washington, grandson of Constance from Book 4, is comatose from a head wound sustained in a drug-related, drive-by shooting. As his spirit drifts between life and death, he is told stories by his faithful grandmother who has camped herself in his hospital room. Through her stories and flashbacks of his youth, Elijah learns about his family line. Meanwhile, fearful drug dealers lurk in the shadows, ready to pull Elijah's life support if he awakens. Will Elijah fight to survive and, in faith, choose life or silently resign to the spirit of death?